貨號	規格	價格	上海	北京	武漢	南京
S81113-1mg	99.3%	￥150.00 S81113-1mg ￥150.00 現貨	4 4	-	-	-
S81113-2mg	99.3%	￥200.00 S81113-2mg ￥200.00 現貨	5 5	-	-	-
S81113-5mg	99.3%	￥290.00 S81113-5mg ￥290.00 現貨	5 5	-	-	-
S81113-10mg	99.3%	￥350.00 S81113-10mg ￥350.00 現貨	6 6	-	-	-
S81113-50mg	99.3%	￥970.00 S81113-50mg ￥970.00 現貨	3 3	-	-	-
S81113-100mg	≥99%	￥1260.00 S81113-100mg ￥1260.00 2-3天	0 貨期：2-3天	-	-	-
S81113-200mg	≥99%	￥2400.00 S81113-200mg ￥2400.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產品

加入購物車

產品介紹

GSK461364 is a selective, reversible and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with a Ki value of 2.2 nM.

產品描述：

GSK461364 is a selective, reversible and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with a Ki value of 2.2 nM.

靶點：

PLK1:2.2 nM (Ki);PLK

體內研究：

GSK461364 (50 mg/kg) exhibits various degrees of tumor growth delay (TGD) in multiple xenograft tumor models by i.p. one dose every 2 days repeated twelve times (q2d×12)

參考文獻：

1. Olmos D, et al. Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies. Clin Cancer Res. 2011 May 15;17(10):3420-30. 2. Degenhardt Y, et al. Sensitivity of cancer cells to Plk1 inhibitor GSK461364A is associated with loss of p53 function and chromosome instability. Mol Cancer Ther. 2010 Jul;9(7):2079-89 3. Gilmartin AG, et al. Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis. Cancer Res. 2009 Sep 1;69(17):6969-77. 4. Chou YS, et al. Cytotoxic mechanism of PLK1 inhibitor GSK461364 against osteosarcoma: Mitotic arrest, apoptosis, cellular senescence, and synergistic effect with paclitaxel. Int J Oncol. 2016 Mar;48(3):1187-94.

溶解性：

DMSO : 50 mg/mL (91.98 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.84 ml	9.198 ml	18.395 ml
5 mM	0.368 ml	1.84 ml	3.679 ml
10 mM	0.184 ml	0.92 ml	1.84 ml
50 mM	0.037 ml	0.184 ml	0.368 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费