貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81081-1mg	98.2%	￥320.00 S81081-1mg ￥320.00 現(xiàn)貨	9 9	-	-	-
S81081-2mg	98.2%	￥480.00 S81081-2mg ￥480.00 現(xiàn)貨	10 10	-	-	-
S81081-5mg	98.2%	￥624.00 S81081-5mg ￥624.00 現(xiàn)貨	8 8	-	-	-
S81081-10mg	98.2%	￥1000.00 S81081-10mg ￥1000.00 現(xiàn)貨	10 10	-	-	-
S81081-25mg	98.2%	￥1920.00 S81081-25mg ￥1920.00 現(xiàn)貨	6 6	-	-	-
S81081-50mg	98.2%	￥3200.00 S81081-50mg ￥3200.00 現(xiàn)貨	3 3	-	-	-
S81081-100mg	≥98%	￥5360.00 S81081-100mg ￥5360.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.

產(chǎn)品描述：

Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.

靶點(diǎn)：

Adenosine Receptor;FLT;Monoamine Transporter;Syk;FLT;?Syk;?MonoamineTransporter;?AdenosineReceptor

體內(nèi)研究：

在人肥大細(xì)胞,巨噬細(xì)胞,和中性粒細(xì)胞中,Fostamatinib能夠特異性抑制FcγR信號(hào)。在大部分DLBCL細(xì)胞系,Fostamatinib誘導(dǎo)細(xì)胞凋亡。Fostamatinib（EC50 =56 nM）以劑量依賴方式抑制抗- IgE介導(dǎo)的CHMC脫粒,它也會(huì)抑制抗-IgE誘導(dǎo)的LTC4,細(xì)胞因子以及趨化因子,包括TNFα,IL-8,和GM-CSF的產(chǎn)生與釋放

細(xì)胞實(shí)驗(yàn)：

Cultured human mast cells (CHMC) are derived from cord blood CD34+ progenitor cells and grown, primed, and stimulated and shown in supplemental data. Before stimulation, cells are incubated with R788 or DMSO for 30 minutes. Cells are then stimulated with either 0.25 to 2 mg/mL anti-IgE or anti-IgG or 2 μM ionomycin. For tryptase measurement, ～1500 cells per well are stimulated for 30 min in modified Tyrode's buffer. For LTC4 and cytokine production, 100,000 cells per well are stimulated for 1 or 7 hours, respectively. Tryptase activity is measured by luminescence readout of a peptide substrate, and LTC4 and cytokines are measured using Luminex multiplex technology. (Only for Reference)

參考文獻(xiàn)：

1.Chen L et al.Blood, 2008, 111(4), 2230-2237. 2.Braselmann S, et al. J Pharmacol Exp Ther, 2006, 319(3), 1998-12008. 3.Suljagic M, et al. Blood, 2010, 116(23), 4894-4905. 4.Bajpai M. IDrugs, 2009, 12(3), 174-185.

溶解性：

Ethanol:<1 mg/mL DMSO:107 mg/mL (184.3 mM) H2O:<1 mg/mL

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.723 ml	8.614 ml	17.228 ml
5 mM	0.345 ml	1.723 ml	3.446 ml
10 mM	0.172 ml	0.861 ml	1.723 ml
50 mM	0.034 ml	0.172 ml	0.345 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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Fostamatinib (R788)