貨號	規格	價格	上海	北京	武漢	南京
S81071-10mg	97.5%	￥260.00 S81071-10mg ￥260.00 現貨	4 4	-	-	-
S81071-50mg	97.5%	￥340.00 S81071-50mg ￥340.00 現貨	5 5	-	-	-
S81071-200mg	97.5%	￥800.00 S81071-200mg ￥800.00 現貨	1 1	-	-	-
S81071-500mg	≥97%	￥1200.00 S81071-500mg ￥1200.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal. DMOG induces cell autophagy

產品描述：

靶點：

HIF-1α prolyl hydroxylase;HIF/HIFProlyl-Hydroxylase;?HIF;?Autophagy

體內研究：

DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats

參考文獻：

1. Baader E, et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues. Biochem J. 1994 Jun 1;300 (Pt 2):525-30. 2. Milkiewicz M, et al. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J Physiol. 2004 Oct 1;560(Pt 1):21-6. 3. Schultz K, et al. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L921-7. 4. Li X, et al. Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):112-8. 5. Singh A, et al. Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.Sci Rep. 2020 Jan 31;10(1):1597.

溶解性：

DMSO : ≥ 50 mg/mL (285.49 mM) H2O : 50 mg/mL (285.49 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	5.71 ml	28.549 ml	57.097 ml
5 mM	1.142 ml	5.71 ml	11.419 ml
10 mM	0.571 ml	2.855 ml	5.71 ml
50 mM	0.114 ml	0.571 ml	1.142 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Dimethyloxaloylglycine