貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京	購(gòu)買(mǎi)數(shù)量
S81068-10mg	99.9%	￥500.00 S81068-10mg ￥500.00 現(xiàn)貨	12 >10	-	-	-
S81068-100mg	99.9%	￥1900.00 S81068-100mg ￥1900.00 現(xiàn)貨	9 9	-	-	-

產(chǎn)品介紹

Manidipine, a calcium channel blocker, which is dihydropyridine type. It is utilized

產(chǎn)品描述：

Manidipine, a calcium channel blocker, which is dihydropyridine type. It is utilized

靶點(diǎn)：

Calcium Channel;CalciumChannel

體內(nèi)研究：

Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. Manidipine combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion. Manidipine hydrochloride prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy. Manidipine HCl increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats.

參考文獻(xiàn)：

1.Yoshiyama M, et al. Jpn Circ J, 1998, 62(1), 47-52. 2.Rossoni G, et al. Eur J Pharmacol, 2008, 587(1-3), 224-230. 3.Roth M, et al. Proc Natl Acad Sci U S A, 1992, 89(9), 4071-4075. 4.Tojo A, et al. J Cardiovasc Pharmacol, 1992, 20(6), 895-899. 5.Huang S, et al. Am Heart J, 1993, 125(2 Pt 2), 589-597.

溶解性：

DMSO:113 mg/mL (185 mM) H2O:<1 mg/mL Ethanol:3 mg/mL (4.91 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.637 ml	8.187 ml	16.375 ml
5 mM	0.327 ml	1.637 ml	3.275 ml
10 mM	0.164 ml	0.819 ml	1.637 ml
50 mM	0.033 ml	0.164 ml	0.327 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(shū)(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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