貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81064-2mg	99.09%	￥170.00 S81064-2mg ￥170.00 現(xiàn)貨	8 8	-	-	-
S81064-5mg	99.09%	￥235.00 S81064-5mg ￥235.00 現(xiàn)貨	4 4	-	-	-
S81064-10mg	99.09%	￥425.00 S81064-10mg ￥425.00 現(xiàn)貨	5 5	-	-	-
S81064-25mg	99.09%	￥850.00 S81064-25mg ￥850.00 現(xiàn)貨	5 5	-	-	-
S81064-50mg	99.09%	￥1445.00 S81064-50mg ￥1445.00 現(xiàn)貨	3 3	-	-	-
S81064-100mg	≥99%	￥2300.00 S81064-100mg ￥2300.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價(jià) 收藏產(chǎn)品

加入購物車

產(chǎn)品介紹

Ganetespib (STA-9090) is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Ganetespib has antiangiogenic effects in colorectal cancer mediated through inhibition of HIF-1α and STAT3

產(chǎn)品描述：

靶點(diǎn)：

HSP90;Apoptosis;?HSP;?HIF

體內(nèi)研究：

Ganetespib (125 mg/kg, i.v.) accumulates in tumors relative to normal tissues and displays greater in vivo efficacy than 17-AAG without increased toxicity and inhibits proliferation and induces apoptosis in parallel with EGFR depletion in NCI-H1975 xenografts. Ganetespib (100, 125, 150 mg/kg, i.v.) shows potent antitumor efficacy in solid and hematologic xenograft models of oncogene addiction, as evidenced by significant growth inhibition and/or regressions

參考文獻(xiàn)：

1. Shimamura T, et al. Ganetespib (STA-9090), a Non-Geldanamycin HSP90 Inhibitor, has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer. Clin Cancer Res. 2012 Jul 17. 2. Ying W, et al. Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy. Mol Cancer Ther. 2012 Feb;11(2):475-84. 3. London CA, et al. Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer. PLoS One. 2011;6(11):e27018. 4. Proia DA, et al. Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS One. 2011 Apr 14;6(4):e18552. 5. Stewart E, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018 Sep 10;34(3):411-426.e19.

溶解性：

DMSO : ≥ 100 mg/mL (274.42 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.744 ml	13.721 ml	27.442 ml
5 mM	0.549 ml	2.744 ml	5.488 ml
10 mM	0.274 ml	1.372 ml	2.744 ml
50 mM	0.055 ml	0.274 ml	0.549 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(COA)?

請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
在貨品標(biāo)簽上如何找到貨號(hào)和批號(hào)?

摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計(jì)算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费