貨號	規格	價格	上海	北京	武漢	南京
S81045-5mg	99.7%	￥50.00 S81045-5mg ￥50.00 現貨	1605 >10	-	-	-
S81045-10mg	99.7%	￥75.00 S81045-10mg ￥75.00 現貨	807 >10	-	-	-
S81045-50mg	99.7%	￥170.00 S81045-50mg ￥170.00 現貨	167 >10	-	-	-
S81045-250mg	99.7%	￥570.00 S81045-250mg ￥570.00 現貨	38 >10	-	-	-

產品介紹

Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.

產品描述：

Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.

靶點：

EC50: 100 nM (G551D-CFTR), 25 nM (F508del-CFTR);CFTR;?Autophagy

體內研究：

Ivacaftor (1-200 mg/kg, p.o.) exhibits good oral bioavailability in rat

參考文獻：

1. Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570 2. Mutyam V, et al. Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation. J Cyst Fibros. 2017 Jan;16(1):24-29 3. Hadida S, et al. Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-9 4. Van Goor F, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.548 ml	12.739 ml	25.478 ml
5 mM	0.51 ml	2.548 ml	5.096 ml
10 mM	0.255 ml	1.274 ml	2.548 ml
50 mM	0.051 ml	0.255 ml	0.51 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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