貨號	規格	價格	上海	北京	武漢	南京
S81041-5mg	99.6%	￥145.00 S81041-5mg ￥145.00 現貨	10 10	-	-	-
S81041-10mg	99.6%	￥220.00 S81041-10mg ￥220.00 現貨	11 >10	-	-	-
S81041-50mg	99.6%	￥640.00 S81041-50mg ￥640.00 現貨	7 7	-	-	-
S81041-250mg	99.6%	￥1800.00 S81041-250mg ￥1800.00 現貨	2 2	-	-	-

產品介紹

Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.

產品描述：

Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.

靶點：

HIV Integrase;HIV;HIVProtease;?Integrase

體內研究：

Raltegravir induces viro-immunological improvement of nonhuman primates with progressing SIVmac251 infection. One non-human primate shows an undetectable viral load following Raltegravir monotherapy

參考文獻：

1. Hare, S., et al., Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A, 2010. 107(46): p. 20057-62. 2. Hicks C, et al. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis. 2009 Apr 1;48(7):931-9 3. Moss DM, et al. Divalent metals and pH alter raltegravir disposition in vitro. Antimicrob Agents Chemother. 2012 Jun;56(6):3020-6 4. Hare S, et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 Oct;80(4):565-72. 5. Lewis, M.G., et al. Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology, 2010. 7: p. 21.

溶解性：

H2O : 25 mg/mL (51.81 mM; Need ultrasonic) DMSO : 20.83 mg/mL (43.17 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.072 ml	10.362 ml	20.725 ml
5 mM	0.414 ml	2.072 ml	4.145 ml
10 mM	0.207 ml	1.036 ml	2.072 ml
50 mM	0.041 ml	0.207 ml	0.414 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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分子摩爾量

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Raltegravir Potassium Salt