貨號	規格	價格	上海	北京	武漢	南京
S81036-5mg	98.8%	￥712.00 S81036-5mg ￥712.00 現貨	5 5	-	-	-
S81036-10mg	98.8%	￥1200.00 S81036-10mg ￥1200.00 現貨	7 7	-	-	-
S81036-50mg	98.8%	￥3600.00 S81036-50mg ￥3600.00 現貨	3 3	-	-	-

產品介紹

MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM.

產品描述：

MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM.

靶點：

Aurora A:4 nM (IC50);CaseinKinase;?PKA;?Src;?AuroraKinase

體內研究：

In the HCT-116 tumor-bearing mice, MLN8054 treatment inhibits tumor growth dose dependently. MLN8054 is generally well tolerated. MLN8054 also inhibits the growth of the PC-3 tumor xenograft in nude mice. MLN8054 Treatment Results in Inhibition of Aurora A, Accumulation of Mitotic Cells, and Apoptosis in vivo. MLN8054 selectively inhibits Aurora A kinase activity when dosed at 30 mg/kg. At this dose in HCT116 tumor tissue, MLN8054 has been shown to inhibit Aurora A autophosphorylation, and induce an increase in the Aurora B substrate, pHisH3

參考文獻：

1. Manfredi MG, et al. Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4106-11. 2. Huck JJ, et al. MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo. Mol Cancer Res. 2010 Mar;8(3):373-84.

溶解性：

DMSO : 20.83 mg/mL (43.68 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.097 ml	10.485 ml	20.971 ml
5 mM	0.419 ml	2.097 ml	4.194 ml
10 mM	0.21 ml	1.049 ml	2.097 ml
50 mM	0.042 ml	0.21 ml	0.419 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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