| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S81031-5mg |
99.0% | ￥60.00 | 9 | - | - | - |
|
S81031-10mg |
99.0% | ￥70.00 | 10 | - | - | - |
|
S81031-50mg |
99.0% | ￥110.00 | 2 | - | - | - |
|
S81031-100mg |
99.0% | ￥190.00 | 5 | - | - | - |
|
S81031-200mg |
99.0% | ￥350.00 | 2 | - | - | - |
|
S81031-1g |
≥99% | ￥990.00 | 貨期：2-3天 | - | - | - |
|
Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.
| 產品描述： | Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | GSK-3β(WT):5 nM (IC50);GSK-3β(C199A):60 nM (IC50);GSK-3 | ||||||||||||||||||||
| 體內研究： | Injection of Tideglusib (NP031112) (50 mg/kg) into the rat hippocampus dramatically reduces kainic acid-induced inflammation, as measured by edema formation using T2-weighted magnetic resonance imaging and glial activation and has a neuroprotective effect in the damaged areas of the hippocampus | ||||||||||||||||||||
| 參考文獻： | 1. Domínguez JM, et al. Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib. J Biol Chem, 2012, 287(2), 893-90 2. Luna-Medina R, et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci, 2007, 27(21), 5766-5776. | ||||||||||||||||||||
| 溶解性： | DMSO : 33.33 mg/mL (99.67 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
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危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京