貨號	規格	價格	上海	北京	武漢	南京
S81009-5mg	98.7%	￥384.00 S81009-5mg ￥384.00 現貨	9 9	-	-	-
S81009-10mg	98.7%	￥600.00 S81009-10mg ￥600.00 現貨	9 9	-	-	-
S81009-50mg	98.7%	￥1920.00 S81009-50mg ￥1920.00 現貨	4 4	-	-	-
S81009-100mg	≥98%	￥3360.00 S81009-100mg ￥3360.00 2-3天	0 貨期：2-3天	-	-	-
S81009-200mg	≥98%	￥5360.00 S81009-200mg ￥5360.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM

產品描述：

BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM

靶點：

EC50: 700 nM (TCF-dependent transcriptional activity);Wnt/beta-catenin

體外研究：

BML-284 (10 μM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen. BML-284 (10 μM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group. Western Blot Analysis Cell Line: Human gastric cancer cell lines MNK45 and AGS Concentration: 10 μM Incubation Time: 24 hours Result: Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells.

體內研究：

BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos

參考文獻：

1. Liu J, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90. 2. Ying Jiang, et al. Pizotifen inhibits the proliferation and invasion of gastric cancer cells. Exp Ther Med. 2020 Feb;19(2):817-824. 3. Yunlong Meng, et al. Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish. Chemosphere. 2020 Sep;255:126889.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.854 ml	14.271 ml	28.541 ml
5 mM	0.571 ml	2.854 ml	5.708 ml
10 mM	0.285 ml	1.427 ml	2.854 ml
50 mM	0.057 ml	0.285 ml	0.571 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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