貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S81003-5mg	≥98%	￥800.00 S81003-5mg ￥800.00 2-3天	0 貨期：2-3天	-	-	-
S81003-25mg	≥98%	￥2400.00 S81003-25mg ￥2400.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.

產(chǎn)品描述：

Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.

靶點：

Guanylate Cyclase;Guanylatecyclase

體內(nèi)研究：

Pharmacokinetic analysis shows very low oral bioavailability (0.10%). In intestinal secretion and transit models, linaclotide exhibits significant pharmacological effects in wt, but not in GC-C null mice: induction of increased fluid secretion into surgically ligated jejunal loops is accompanied by the secretion of elevated levels of cyclic guanosine-3',5-monophosphate and accelerated gastrointestinal transit. Linaclotide significantly increases weekly spontaneous bowel movements and complete spontaneous bowel movements (CSBMs) while reducing abdominal pain in patients with chronic constipation

參考文獻：

1. Bryant AP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86(19-20):760-5. 2. Love BL, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71(13):1081-91.

溶解性：

DMSO : 50 mg/mL (32.75 mM; Need ultrasonic) H2O : 16.67 mg/mL (10.92 mM; ultrasonic and adjust pH to 2 with HCl)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	0.655 ml	3.275 ml	6.55 ml
5 mM	0.131 ml	0.655 ml	1.31 ml
10 mM	0.065 ml	0.327 ml	0.655 ml
50 mM	0.013 ml	0.065 ml	0.131 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=1.61] Xin-Yi Liu et al."Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH.

質(zhì)檢證書(COA)

輸入產(chǎn)品批號：

如何獲取質(zhì)檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费