貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80993-5mg	98.3%	￥197.00 S80993-5mg ￥197.00 現(xiàn)貨	10 10	-	-	-
S80993-50mg	98.3%	￥500.00 S80993-50mg ￥500.00 現(xiàn)貨	6 6	-	-	-
S80993-25mg	98.3%	￥666.00 S80993-25mg ￥666.00 現(xiàn)貨	8 8	-	-	-
S80993-100mg	98.3%	￥700.00 S80993-100mg ￥700.00 現(xiàn)貨	1 1	-	-	-

產(chǎn)品介紹

BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively

產(chǎn)品描述：

BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively

靶點(diǎn)：

HSP90:1.7 nM (Ki);HSP90:38 nM (EC50);HSP;Autophagy

體內(nèi)研究：

Oral administration of BIIB021 leads to tumor growth inhibition in many tumor xenograft models including N87, BT474, CWR22, U87, SKOV3 and Panc-1. BIIB021 effectively inhibits growth of L540cy tumor at a dose of 120 mg/kg. BIIB021 significantly enhances antitumor growth effect of radiation in JHU12 xenograf].

參考文獻(xiàn)：

1. Lundgren, Karen., et al. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Molecular Cancer Therapeutics (2009), 8(4), 921-929. 2. B?ll B, et al. Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity. Clin Cancer Res. 2009 Aug 15;15(16):5108-16. 3. Yin X, et al. BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int J Cancer. 2010 Mar 1;126(5):1216-25 4. Zhang H, et al. BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance. Int J Cancer. 2010 Mar 1;126(5):1226-34

溶解性：

DMSO : ≥ 45 mg/mL (141.17 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.137 ml	15.685 ml	31.371 ml
5 mM	0.627 ml	3.137 ml	6.274 ml
10 mM	0.314 ml	1.569 ml	3.137 ml
50 mM	0.063 ml	0.314 ml	0.627 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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