貨號	規格	價格	上海	北京	武漢	南京	購買數量
S80990-5mg	99.5%	￥480.00 S80990-5mg ￥480.00 現貨	6 6	-	-	-
S80990-25mg	99.5%	￥1440.00 S80990-25mg ￥1440.00 現貨	13 >10	-	-	-

產品介紹

ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.

產品描述：

靶點：

Wnt/beta-catenin;Epigenetic Reader Domain;EpigeneticReaderDomain;Wnt/beta-catenin

體內研究：

PRI-724 exhibits antitumor activity in the mouse xenograft models of colon cancer. The initial results of the Phase I clinic trial of PRI-724 has been disclosed publically. The drug exhibits an acceptable toxicity profile with only one dose-limiting toxicity of grade 3 reversible hyperbilirubinaemia. An Open-Label dose-escalation phase I/II study of PRI-724 for patients with advanced myeloid malignancies is still ongoing

細胞實驗：

ICG-001 is dissolved in DMSO. To evaluate effects of ICG-001 on α-SMA and collagen type 1 expression, RLE-6TN cells are treated with TGF-β1 (0.25 ng/mL) in the presence or absence of ICG-001 (5.0 μM). After 24 h, cells are harvested and mRNA isolated for analysis by qPCR. RNA is reverse-transcribed using SuperScript reverse transcriptase. Quantitative PCR is performed with SYBR-Green PCR using Real-Time PCR System HT7900. The amplification protocol is set as follows: 95°C denaturation for 10 min followed by 40 cycles of 15-s denaturation at 95°C, 1 min of annealing/extension, and data collection at 60°C.

參考文獻：

1.Yosuke Osawa, et al. EBioMedicine. 2015, 2(11):1751-1758. 2.Liu F, Yu F, Lu Y Z, et al. Crosstalk between pleural mesothelial cell and lung fibroblast contributes to pulmonary fibrosis[J]. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2020, 1867(11): 118806. 3.Sasaki T, et al. Transl Respir Med. 2:8. 4.Zhang X, et al. Am J Cancer Res. 2015, 5(8):2344-2360.

溶解性：

DMSO:54.9 mg/mL (100 mM) Ethanol:27.4 mg/mL (50 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.823 ml	9.114 ml	18.227 ml
5 mM	0.365 ml	1.823 ml	3.645 ml
10 mM	0.182 ml	0.911 ml	1.823 ml
50 mM	0.036 ml	0.182 ml	0.365 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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(S,S)-ICG 001