貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80989-5mg	99.5%	￥390.00 S80989-5mg ￥390.00 現(xiàn)貨	6 6	-	-	-
S80989-10mg	99.5%	￥580.00 S80989-10mg ￥580.00 現(xiàn)貨	7 7	-	-	-
S80989-50mg	99.5%	￥1490.00 S80989-50mg ￥1490.00 現(xiàn)貨	2 2	-	-	-

產(chǎn)品介紹

VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC50 of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5 μM, respectively.

產(chǎn)品描述：

靶點(diǎn)：

HSP90β:58 nM (IC50);GRP94:4.1 μM (IC50);TRAP-1:5.5 μM (IC50);HSP

體內(nèi)研究：

VER-82576 (NVP-BEP800; 15 or 30 mg/kg, p.o.) shows antitumor activities in A375 cancer xenografts and BT-474 xenograft-bearing mice

參考文獻(xiàn)：

1. Massey AJ, et al. Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. Mol Cancer Ther. 2010 Apr;9(4):906-19. 2. Niewidok N, et al. Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity. Transl Oncol. 2012 Oct;5(5):356-69. Epub 2012 Oct 1. 3. Wu J, et al. Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70. Exp Ther Med. 2014 Sep;8(3)

溶解性：

DMSO : 6.2 mg/mL (12.91 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.082 ml	10.408 ml	20.815 ml
5 mM	0.416 ml	2.082 ml	4.163 ml
10 mM	0.208 ml	1.041 ml	2.082 ml
50 mM	0.042 ml	0.208 ml	0.416 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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