貨號	規(guī)格	價格	上海	北京	武漢	南京
S80983-2mg	98.1%	￥280.00 S80983-2mg ￥280.00 現(xiàn)貨	1 1	-	-	-
S80983-5mg	98.1%	￥400.00 S80983-5mg ￥400.00 現(xiàn)貨	5 5	-	-	-
S80983-10mg	98.1%	￥560.00 S80983-10mg ￥560.00 現(xiàn)貨	3 3	-	-	-
S80983-25mg	98.1%	￥960.00 S80983-25mg ￥960.00 現(xiàn)貨	5 5	-	-	-
S80983-50mg	98.1%	￥1520.00 S80983-50mg ￥1520.00 現(xiàn)貨	4 4	-	-	-
S80983-100mg	98.1%	￥2800.00 S80983-100mg ￥2800.00 現(xiàn)貨	5 5	-	-	-

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產(chǎn)品介紹

A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM.

產(chǎn)品描述：

A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM.

靶點：

AMPK:0.8 μM (EC50);AMPK;FattyAcidSynthase

體內(nèi)研究：

A-769662 (30 mg/kg, i.p.) significantly reduced the respiratory exchange ratio (RER) in the SD rat. There are 33% and 58% reductions of malonyl CoA levels in livers of animals treated with 30 mg/kg A-769662 (0.905 nmol/g) or 500 mg/kg metformin (0.574 nmol/g), respectively. A-769662 (30 mg/kg, b.i.d.) significantly decreases fed plasma glucose (30%-40% reduction), while the lower doses (3 and 10 mg/kg) of A-769662 had no effect on the in diabetic ob/ob mice

參考文獻：

1. Cool B, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab, 2006, 3(6), 403-416. 2. Sanders MJ, et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem, 2007, 282(45), 32539-32548. 3. Moreno D, et al, A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism. FEBS Lett, 2008, 583(17), 2650-2654. [Content Brief] 4. Yerra VG, et al. Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation. Mol Neurobiol. 2017 Apr;54

溶解性：

DMSO : 50 mg/mL (138.74 mM; ultrasonic and warming and heat to 80°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.775 ml	13.874 ml	27.748 ml
5 mM	0.555 ml	2.775 ml	5.55 ml
10 mM	0.277 ml	1.387 ml	2.775 ml
50 mM	0.055 ml	0.277 ml	0.555 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=5.4] Jianchao Si et al."Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway."JOURNAL OF ETHNOPHARMACOLOGY.2023 Oct;315:116677

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A-769662

4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile