貨號	規格	價格	上海	北京	武漢	南京
S80982-1mg	98.9%	￥197.00 S80982-1mg ￥197.00 現貨	8 8	-	-	-
S80982-5mg	98.9%	￥198.00 S80982-5mg ￥198.00 現貨	7 7	-	-	-
S80982-25mg	98.9%	￥590.00 S80982-25mg ￥590.00 現貨	8 8	-	-	-
S80982-100mg	98.9%	￥1490.00 S80982-100mg ￥1490.00 現貨	7 7	-	-	-

產品介紹

R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)

產品描述：

靶點：

Ki: 30 nM (Syk) IC50: 41 nM (Syk) FLT3 IC50: 63 nM (Lyn), 37 nM (Lck);Apoptosis;FLT;Syk

體內研究：

R406 (5 and 10 mg/kg) shows efficacy in the amelioration of the Arthus reaction and in reducing clinical symptoms in the collagen antibody-induced arthritis (CAIA) and K/BxN models of rheumatoid arthritis (RA). Immune complex (IC)-mediated inflammation is reduced by inhibition of Fc receptor signaling with R406

參考文獻：

1. Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. 2. Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317(2):571-8.

溶解性：

DMSO : ≥ 61 mg/mL (97.04 mM) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.591 ml	7.954 ml	15.908 ml
5 mM	0.318 ml	1.591 ml	3.182 ml
10 mM	0.159 ml	0.795 ml	1.591 ml
50 mM	0.032 ml	0.159 ml	0.318 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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