貨號	規格	價格	上海	北京	武漢	南京
S80970-10mg	99.9%	￥50.00 S80970-10mg ￥50.00 現貨	10 10	-	-	-
S80970-50mg	99.9%	￥85.00 S80970-50mg ￥85.00 現貨	11 >10	-	-	-
S80970-250mg	99.9%	￥210.00 S80970-250mg ￥210.00 現貨	9 9	-	-	-
S80970-1g	99.9%	￥530.00 S80970-1g ￥530.00 現貨	7 7	-	-	-

產品介紹

Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).

產品描述：

Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).

靶點：

Adrenergic Receptor;AdrenergicReceptor

體內研究：

Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat.

參考文獻：

1.Palea S, et al. BJU Int,2003, 91(9), 873-877. 2.Lacerda AE, et al. J Pharmacol Exp Ther,2008, 324(2), 427-433. 3.Tambaro S, et al. J Pharmacol Exp Ther,2005, 312(2), 710-717. 4.Mayoux E, et al. Eur Urol,2004, 45(1), 110-116. 5.Lefèvre-Borg F, et al. Br J Pharmacol. 1993 Aug;109(4):1282-9.

溶解性：

DMSO:10.7 mg/mL (25 mM) H2O:10.7 mg/mL (25 mM)

保存條件：

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.348 ml	11.74 ml	23.479 ml
5 mM	0.47 ml	2.348 ml	4.696 ml
10 mM	0.235 ml	1.174 ml	2.348 ml
50 mM	0.047 ml	0.235 ml	0.47 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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濃度

體積

分子摩爾量

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