貨號	規格	價格	上海	北京	武漢	南京
S80962-5mg	≥99%	￥500.00 S80962-5mg ￥500.00 現貨	106 >10	-	-	-
S80962-10mg	≥99%	￥800.00 S80962-10mg ￥800.00 現貨	56 >10	-	-	-
S80962-25mg	≥99%	￥1750.00 S80962-25mg ￥1750.00 現貨	26 >10	-	-	-
S80962-50mg	≥99%	￥2800.00 S80962-50mg ￥2800.00 現貨	15 >10	-	-	-

產品介紹

Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

產品描述：

Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

靶點：

IL-6;IL-1;STAT3;Lipoxygenase;STAT;Interleukin

體內研究：

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug

參考文獻：

1. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61. 2. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

溶解性：

Soluble in DMSO、1M NaOH

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.799 ml	13.993 ml	27.986 ml
5 mM	0.56 ml	2.799 ml	5.597 ml
10 mM	0.28 ml	1.399 ml	2.799 ml
50 mM	0.056 ml	0.28 ml	0.56 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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