貨號	規格	價格	上海	北京	武漢	南京
S80958-5mg	98.6%	￥578.00 S80958-5mg ￥578.00 現貨	4 4	-	-	-
S80958-10mg	98.6%	￥1020.00 S80958-10mg ￥1020.00 現貨	4 4	-	-	-
S80958-50mg	98.6%	￥3825.00 S80958-50mg ￥3825.00 現貨	2 2	-	-	-
S80958-100mg	≥98%	￥6200.00 S80958-100mg ￥6200.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

GSK256066 is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK256066 is developed for the research of chronic obstructive pulmonary disease

產品描述：

GSK256066 is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK256066 is developed for the research of chronic obstructive pulmonary disease

靶點：

PDE4:3.2 pM (IC50);PDE

體內研究：

GSK256066 (10 μg/kg; i.t.) causes significant inhibition of LPS-induced pulmonary neutrophilia. GSK256066 also inhibits LPS-induced increases in exhaled nitric oxide (ED50=92 μg/kg). GSK256066 inhibits pulmonary eosinophilia in rats exposed to ovalbumin (ED50=0.4 μg/kg)

參考文獻：

1. Tralau-Stewart CJ, et al. GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization. J Pharmacol Exp Ther, 2011, 337(1), 145-154. 2. Nials AT, et al. In vivo characterization of GSK256066, a high-affinity inhaled phosphodiesterase 4 inhibitor. J Pharmacol Exp Ther, 2011, 337(1), 137-144.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.928 ml	9.642 ml	19.283 ml
5 mM	0.386 ml	1.928 ml	3.857 ml
10 mM	0.193 ml	0.964 ml	1.928 ml
50 mM	0.039 ml	0.193 ml	0.386 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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