貨號	規格	價格	上海	北京	武漢	南京
S80953-5mg	≥99%	￥500.00 S80953-5mg ￥500.00 2-3天	0 貨期：2-3天	-	-	-
S80953-10mg	≥99%	￥750.00 S80953-10mg ￥750.00 2-3天	0 貨期：2-3天	-	-	-
S80953-50mg	≥99%	￥2250.00 S80953-50mg ￥2250.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

L-165041 is a cell permeable PPARδ agonist, with Kis of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively, and induces adipocyte differentiation in NIH-PPARδ cells.

產品描述：

L-165041 is a cell permeable PPARδ agonist, with Kis of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively, and induces adipocyte differentiation in NIH-PPARδ cells.

靶點：

PPARδ:6 nM (Ki);PPARγ:730 nM (Ki);PPAR

體內研究：

L-165041 (5 mg/kg/day, i.p.) significantly lowers the formation of lipid droplets in mice. L-165041 markedly reduces the level of both the hepatic cholesterol and triglycerides in mice. L-165041 increases mRNA expression levels of PPARδ compared to the vehicle group. Lipoprotein lipase (LPL) expression in L-165041-treated mice is significantly higher than that in the vehicle group

參考文獻：

1. Berger J, et al. Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25. 2. Park, Jin-Hee., et al. The PPARδ ligand L-165041 inhibits vegf-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ. Journal of Cellular Biochemistry (2012), 113(6), 1947-1954. 3. Lim, Hyun-Joung., et al. PPARδ ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice. European Journal of Pharmacology (2009), 622(1-3), 45-51. 4. Lim, Hyun-Joung., et al. PPARδ agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle. Atherosclerosis (Amsterdam, Netherlands) (2009), 202(2), 446-454.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.485 ml	12.424 ml	24.848 ml
5 mM	0.497 ml	2.485 ml	4.97 ml
10 mM	0.248 ml	1.242 ml	2.485 ml
50 mM	0.05 ml	0.248 ml	0.497 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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L-165,041