貨號	規格	價格	上海	北京	武漢	南京
S80943-1mg	98.5%	￥255.00 S80943-1mg ￥255.00 現貨	5 5	-	-	-
S80943-2mg	98.5%	￥459.00 S80943-2mg ￥459.00 現貨	5 5	-	-	-
S80943-5mg	98.5%	￥680.00 S80943-5mg ￥680.00 現貨	5 5	-	-	-
S80943-10mg	98.5%	￥1190.00 S80943-10mg ￥1190.00 現貨	6 6	-	-	-
S80943-25mg	98.5%	￥2380.00 S80943-25mg ￥2380.00 現貨	6 6	-	-	-
S80943-50mg	98.5%	￥4590.00 S80943-50mg ￥4590.00 現貨	5 5	-	-	-
S80943-100mg	≥98%	￥7300.00 S80943-100mg ￥7300.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively

產品描述：

靶點：

IC50: 5.5 nM (FAK), 3.5 nM (Pyk2), 140 nM (IGF-IR), 40 nM (InsR), 0.16 μM (c-Met), 0.36 μM (KDR), 0.48 μM (Flt3);Apoptosis;FAK;c-Met/HGFR;PYK2;IGF-1R

體內研究：

Treatment with NVP-TAE 226 (TAE226) at 50 or 75 mg/kg extends the median survival of U87 xenograft animals by 6 and 7 days, respectively (P=0.084 and P=0.042, respectively, compared with vehicle-treated animals). However, NVP-TAE 226 treatment of LN229-engrafted animals significantly prolongs their median survival by 19 days (P<0.004 for both dosages, compared with vehicle-treated animals)

參考文獻：

1. Liu TJ, et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther, 2007, 6(4), 1357-1367. 2. Delimont D, et al. Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. PLoS One. 2014 Jun 10;9(6):e99083. 3. Lietha D, et al. Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS One. 2008;3(11):e3800.

溶解性：

DMSO : 11.11 mg/mL (23.69 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.132 ml	10.662 ml	21.325 ml
5 mM	0.426 ml	2.132 ml	4.265 ml
10 mM	0.213 ml	1.066 ml	2.132 ml
50 mM	0.043 ml	0.213 ml	0.426 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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TAE226 (NVP-TAE226)