| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S80931-5mg |
≥99% | ￥204.00 | 貨期：2-3天 | - | - | - |
|
S80931-10mg |
99.5% | ￥272.00 | 8 | - | - | - |
|
S80931-25mg |
≥99% | ￥489.60 | 貨期：2-3天 | - | - | - |
|
S80931-50mg |
≥99% | ￥680.00 | 貨期：2-3天 | - | - | - |
|
S80931-100mg |
99.5% | ￥1224.00 | 3 | - | - | - |
|
S80931-200mg |
≥99% | ￥2380.00 | 貨期：2-3天 | - | - | - |
|
S80931-250mg |
≥99% | ￥2720.00 | 貨期：2-3天 | - | - | - |
|
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β
| 產品描述： | VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | p38α MAPK;p38MAPK;Autophagy | ||||||||||||||||||||
| 體內研究： | The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score. | ||||||||||||||||||||
| 參考文獻： | 1. Kuliopulos A, et al. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb Haemost, 2004, 92(6), 1387-1393. 2. Braddock M, IDDB Meeting Report, 2005, March 14-15. 3. Gill A, IDDB Meeing Report, 2002, March 06-08. 4. Naka K, et al. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2015 Aug 20;6:8039. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 42 mg/mL (103.88 mM) | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
滬公網安備 31011702002021號
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京