貨號	規格	價格	上海	北京	武漢	南京
S80930-5mg	≥98%	￥270.00 S80930-5mg ￥270.00 現貨	98 >10	-	-	-
S80930-10mg	99.5%	￥480.00 S80930-10mg ￥480.00 現貨	52 >10	-	-	-
S80930-50mg	99.5%	￥1400.00 S80930-50mg ￥1400.00 現貨	14 >10	-	-	-

產品介紹

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases

產品描述：

靶點：

Human Endogenous Metabolite;EndogenousMetabolite;ProstaglandinReceptor

體外研究：

Prostaglandin E1 (1 nM-10 μM; 48 h) concentration-dependently reduces HUVECs proliferation (up to 100% inhibition) in the presence of VEGF (20 ng/mL), with an IC50 of 400 nM.
Prostaglandin E1 (0.01-10 μM; 6 h) inhibits VEGF-induced HUVECs migration in a concentration dependent manner, with an IC50 of 500 nM.
Prostaglandin E1 (1-5 μM; 12-18 h) inhibits in vitro angiogenesis.
Prostaglandin E1 (0.01-10 μM; 20 min) increases intracellular cAMP levels in HUVECs.

體內研究：

Prostaglandin E1 (20 ng/animal/day; s.c. for 4 days) significantly inhibits the FGF-induced angiogenesis in mice. Animal Model: C57/bl6 female mice (6-8 weeks) were injected with Matrigel supplemented with aFGF and heparin Dosage: 20 ng/day/animal Administration: Minipump placed subcutaneously for 4 days Result: Visibly reduced the neovascularization process.

參考文獻：

1. Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. 2. Cattaneo MG, et, al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. Br J Pharmacol. 2003 Jan;138(2):377-85. 3. Hauck EW, et, al. Prostaglandin E1 long-term self-injection programme for treatment of erectile dysfunction--a follow-up of at least 5 years. Andrologia. 1999;31 Suppl 1:99-103.

溶解性：

EtOH：40mg/ml，DMSO：40mg/ml

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.821 ml	14.105 ml	28.21 ml
5 mM	0.564 ml	2.821 ml	5.642 ml
10 mM	0.282 ml	1.411 ml	2.821 ml
50 mM	0.056 ml	0.282 ml	0.564 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=13.281] Ting Li et al.Engineered Platelet-Based Micro/Nanomotors for Cancer Therapy.Small.2021 Nov 05

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Alprostadil

7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)heptanoic acid