貨號	規格	價格	上海	北京	武漢	南京
S80925-5mg	99.1%	￥570.00 S80925-5mg ￥570.00 現貨	9 9	-	-	-
S80925-10mg	99.1%	￥910.00 S80925-10mg ￥910.00 現貨	8 8	-	-	-
S80925-25mg	99.1%	￥1670.00 S80925-25mg ￥1670.00 現貨	7 7	-	-	-
S80925-100mg	99.1%	￥4200.00 S80925-100mg ￥4200.00 現貨	7 7	-	-	-

產品介紹

Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.

產品描述：

Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.

靶點：

PDE3;PDE

體內研究：

Pimobendan (UD-CG115) shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. Administration of Pimobendan (UD-CG115) significantly increases the final survival rate from 33.6% (control) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg). Pimobendan (UD-CG115) (1 mg/kg) also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. Pimobendan (UD-CG115) suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production

參考文獻：

1. Kajimoto K, et al. Contribution of phosphodiesterase isozymes to the regulation of the L-type calcium current in human cardiac myocytes. Br J Pharmacol. 1997 Aug;121(8):1549-56. 2. Iwasaki A, et al. Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. J Am Coll Cardiol. 1999 Apr;33(5):1400-7.

溶解性：

DMSO : 50 mg/mL (149.53 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.991 ml	14.953 ml	29.907 ml
5 mM	0.598 ml	2.991 ml	5.981 ml
10 mM	0.299 ml	1.495 ml	2.991 ml
50 mM	0.06 ml	0.299 ml	0.598 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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