貨號	規格	價格	上海	北京	武漢	南京
S80922-1mg	98.3%	￥290.00 S80922-1mg ￥290.00 現貨	4 4	-	-	-
S80922-2mg	98.3%	￥510.00 S80922-2mg ￥510.00 現貨	5 5	-	-	-
S80922-5mg	98.3%	￥800.00 S80922-5mg ￥800.00 現貨	6 6	-	-	-
S80922-10mg	98.3%	￥1200.00 S80922-10mg ￥1200.00 現貨	5 5	-	-	-
S80922-25mg	98.3%	￥1740.00 S80922-25mg ￥1740.00 現貨	6 6	-	-	-
S80922-50mg	98.3%	￥2150.00 S80922-50mg ￥2150.00 現貨	5 5	-	-	-

產品介紹

Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.

產品描述：

Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.

靶點：

hHDAC3:157 nM (IC50);hHDAC1:198 nM (IC50);hHDAC11:292 nM (IC50);hHDAC6:315 nM (IC50);hHDAC2:325 nM (IC50);hHDAC10:340 nM (IC50);hHDAC7:524 nM (IC50);hHDAC5:532 nM (IC50);hHDAC9:541 nM (IC50);hHDAC8:854 nM (IC50);hHDAC4:1059 nM (IC50);HD1-B:7.5 nM (IC50);HD1-A ;16 nM (IC50);HD2 ;10 nM (IC50);HDAC

體內研究：

Givinostat (ITF2357) at 10 mg/kg is used as a positive control and, as expected, reduced serum TNFα by 60%. Strikingly, pretreatment of ITF3056 starting at 0.1 mg/kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg/kg), and blood is collected after 4 h. Similarly, when pretreated with lower doses of Givinostat (ITF2357) (1 or 5 mg/kg), there is a 22% reduction for 1 mg/kg and 40% for 5 mg/kg

參考文獻：

1. Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78. 2. Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39. 3. Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.101 ml	10.505 ml	21.01 ml
5 mM	0.42 ml	2.101 ml	4.202 ml
10 mM	0.21 ml	1.05 ml	2.101 ml
50 mM	0.042 ml	0.21 ml	0.42 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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