貨號	規(guī)格	價格	上海	北京	武漢	南京
S80917-10mg	99.4%	￥382.00 S80917-10mg ￥382.00 現(xiàn)貨	6 6	-	-	-
S80917-50mg	99.4%	￥1487.00 S80917-50mg ￥1487.00 現(xiàn)貨	4 4	-	-	-
S80917-100mg	99.4%	￥2100.00 S80917-100mg ￥2100.00 現(xiàn)貨	5 5	-	-	-

產(chǎn)品介紹

Pirarubicin is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

產(chǎn)品描述：

Pirarubicin is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

靶點(diǎn)：

Topoisomerase II;Topoisomerase;Antibacterial;Antibiotic;Autophagy

體內(nèi)研究：

Pirarubicin (18 mg/kg, i.v.) significantly elevates serum level of BNP, CK-MB, CTnT, LDH, and MDA compared with those in the control group in acute cardiac toxicity rats. Pirarubicin also lowers heart rate, and depresses R-wave voltage, and prolongation of QT intervals in the acute cardiac toxicity model

參考文獻(xiàn)：

1. Takigawa N, et al. Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines. Gan To Kagaku Ryoho. 1993 May;20(7):929-35. 2. Nagai K, et al. Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells. Cancer Chemother Pharmacol. 2002 Mar;49(3):244-50. Epub 2002 Jan 8. 3. Li K, et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5. 4. Wang YD, et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2017 Oct 27:1-13.

溶解性：

DMSO : 10 mg/mL (15.93 mM; ultrasonic and warming and heat to 80°C)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.593 ml	7.966 ml	15.933 ml
5 mM	0.319 ml	1.593 ml	3.187 ml
10 mM	0.159 ml	0.797 ml	1.593 ml
50 mM	0.032 ml	0.159 ml	0.319 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(1篇)

1. [IF=4.4] Qu Minmin et al."Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells."Frontiers in Pharmacology.2024 Jun;15:

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