貨號	規(guī)格	價格	上海	北京	武漢	南京
S80911-5mg	96.4%	￥476.00 S80911-5mg ￥476.00 現(xiàn)貨	6 6	-	-	-
S80911-10mg	96.4%	￥816.00 S80911-10mg ￥816.00 現(xiàn)貨	8 8	-	-	-
S80911-25mg	96.4%	￥1496.00 S80911-25mg ￥1496.00 現(xiàn)貨	7 7	-	-	-
S80911-100mg	96.4%	￥4760.00 S80911-100mg ￥4760.00 現(xiàn)貨	4 4	-	-	-

產(chǎn)品介紹

PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively

產(chǎn)品描述：

PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively

靶點：

IC50: 1.5 nM (FAK), 13 nM (Pyk2), 30 nM (CDK2), 47 nM (CDK3), 58 nM (CDK1), 97 nM (CDK7), 97 nM (Flt3);FAK;PYK2;CDK

體內(nèi)研究：

PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (calculated EC50 of 93 ng/mL, total) after p.o. administration to tumor-bearing mice. Rats that receive PF-562271 demonstrate a decrease in tumor growth after 2 weeks of treatment with signs of bone healing as evidenced by the deposition of new bone (cortical and cancellous) at sites previously damaged by the tumor

參考文獻：

1. Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944. 2. Crompton BD, et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res. 2013 May 1;73(9):2873-83. 3. Bagi CM, et al. Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases. Cancer. 2008 May 15;112(10):2313-21.

溶解性：

DMSO : 125 mg/mL (246.31 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.97 ml	9.852 ml	19.705 ml
5 mM	0.394 ml	1.97 ml	3.941 ml
10 mM	0.197 ml	0.985 ml	1.97 ml
50 mM	0.039 ml	0.197 ml	0.394 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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PF-562271