貨號	規格	價格	上海	北京	武漢	南京
S80898-5mg	99.4%	￥280.00 S80898-5mg ￥280.00 現貨	6 6	-	-	-
S80898-10mg	99.4%	￥480.00 S80898-10mg ￥480.00 現貨	9 9	-	-	-
S80898-50mg	99.4%	￥1680.00 S80898-50mg ￥1680.00 現貨	7 7	-	-	-

產品介紹

IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ

產品描述：

靶點：

CK1δ:40 nM (IC50);CaseinKinase;Wnt/beta-catenin;Porcupine

體內研究：

To evaluate the efficacy of IWP-2 in vivo, 200 μL each of IWP-2-liposome or free liposome i separately injected into C57BL/6 mice intraperitoneally about 2 h before injection of a similar volume of either blue-dye-filled latex beads or E. coli DH5α. IWP-2 causes significant reduction in the uptake of blue beads as well as E. coli as assessed by CFUs in peritoneal lavage cells within 2 h. In addition, the levels of TNF-α and IL-6 in the lavage fluid of the corresponding mice are reduced by 2-4-fold compared with control values. Interestingly, IWP-2 even induces a considerable increase in secretion of the anti-inflammatory cytokine IL-10

參考文獻：

1. Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7. 2. García-Reyes B, et al. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. J Med Chem. 2018 May 10;61(9):4087-4102. 3. Maiti G, et al. The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16600-5.

溶解性：

DMF : 12.5 mg/mL (26.79 mM; ultrasonic and warming and heat to 60°C) DMSO : 2 mg/mL (4.29 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.143 ml	10.716 ml	21.432 ml
5 mM	0.429 ml	2.143 ml	4.286 ml
10 mM	0.214 ml	1.072 ml	2.143 ml
50 mM	0.043 ml	0.214 ml	0.429 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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