貨號	規格	價格	上海	北京	武漢	南京
S80892-5mg	99.8%	￥280.00 S80892-5mg ￥280.00 現貨	10 10	-	-	-
S80892-10mg	99.8%	￥520.00 S80892-10mg ￥520.00 現貨	3 3	-	-	-
S80892-25mg	99.8%	￥1040.00 S80892-25mg ￥1040.00 現貨	3 3	-	-	-
S80892-50mg	99.8%	￥2000.00 S80892-50mg ￥2000.00 現貨	3 3	-	-	-

產品介紹

4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation

產品描述：

靶點：

Estrogen receptor:3.3 nM (IC50);CRISPR/Cas9 ;EstrogenReceptor/ERR;Estrogen/progestogenReceptor

體內研究：

4-Hydroxytamoxifen (0.2, 1 and 5 μg/day, p.o.) causes a dose-related decrease in uterine wet weight of immature rats. 4-Hydroxytamoxifen (6 μg/0.1 mL sesame oil/day, s.c.) effectively attenuates methamphetamine-induced nigrostriatal dopamine depletions in bothsexes of intact and gonadectomized C57BL/6 J mice. 4-Hydroxytamoxifen does not alter the dopamine content levels in the striatum

參考文獻：

1. Jordan VC, et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol. 1977 Nov;75(2):305-16. 2. Davis KM, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11(5):316-8. 3. Kuo YM, et al. 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. J Neurochem. 2003 Dec;87(6):1436-43. 4. Zhang J, et al. Drug Inducible CRISPR/Cas Systems. Comput Struct Biotechnol J. 2019;17:1171-1177.

溶解性：

DMSO : 50 mg/mL (129.03 mM; ultrasonic and warming and heat to 60°C) Ethanol : 20 mg/mL (51.61 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.581 ml	12.903 ml	25.806 ml
5 mM	0.516 ml	2.581 ml	5.161 ml
10 mM	0.258 ml	1.29 ml	2.581 ml
50 mM	0.052 ml	0.258 ml	0.516 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=12.2] Ruonan He et al."A genetically encoded fluorescent whole-cell biosensor for real-time detecting estrogenic activities in water samples."JOURNAL OF HAZARDOUS MATERIALS.2025 Mar;485:136903

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