貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80853-5mg	≥98%	￥340.00 S80853-5mg ￥340.00 現(xiàn)貨	5 5	-	-	-
S80853-10mg	≥98%	￥610.00 S80853-10mg ￥610.00 現(xiàn)貨	4 4	-	-	-
S80853-25mg	≥98%	￥1111.00 S80853-25mg ￥1111.00 現(xiàn)貨	3 3	-	-	-
S80853-50mg	≥98%	￥1970.00 S80853-50mg ￥1970.00 現(xiàn)貨	2 2	-	-	-
S80853-100mg	≥98%	￥3161.00 S80853-100mg ￥3161.00 現(xiàn)貨	1 1	-	-	-

產(chǎn)品介紹

LY404039 is a potent, selective and orally active mGluR2 and mGluR3 agonist with Kis of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects

產(chǎn)品描述：

靶點(diǎn)：

mGlu2 Receptor:149 nM (Ki, Recombinant human mGluR2);hmGluR3:92 nM (Ki);GlucocorticoidReceptor;GluR

體內(nèi)研究：

LY404039 attenuates amphetamine- and phencyclidine-induced hyperlocomotion (3-30 and 10 mg/kg, respectively). LY404039 (3-10 mg/kg) inhibits conditioned avoidance responding. LY404039 also reduces fear-potentiated startle in rats (3-30 μg/kg) and marble burying in mice (3-10 mg/kg), indicating anxiolytic-like effects. LY404039 (10 mg/kg) also increases dopamine and serotonin release/turnover in the prefrontal cortex. Following oral administration of LY404039 to fasted rats at doses of 1, 3, or 10 mg/kg, exposure increased proportionally with dose. LY404039 (10 mg/kg; p.o.) treatment shows the Cmax is 1528.5 ng/mL and Tmax is 2 hours in rats

參考文獻(xiàn)：

1. Linda M Rorick-Kehn, et al. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]- 2. Seeman P. An agonist at glutamate and dopamine D2 receptors, LY404039. Neuropharmacology. 2013 Mar;66:87-8. [Content Brief] 3. Rorick-Kehn LM, et al. In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonistLY404039 in animal models of psychiatric disorders. Psychopharmacology (Berl). 2007 Jul;193(1):121-36.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.252 ml	21.258 ml	42.515 ml
5 mM	0.85 ml	4.252 ml	8.503 ml
10 mM	0.425 ml	2.126 ml	4.252 ml
50 mM	0.085 ml	0.425 ml	0.85 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(shū)(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(shū)(COA)?

請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
在貨品標(biāo)簽上如何找到貨號(hào)和批號(hào)?

摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計(jì)算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

LY404039

(1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide