貨號	規(guī)格	價格	上海	北京	武漢	南京
S80825-2mg	99.6%	￥212.50 S80825-2mg ￥212.50 現(xiàn)貨	9 9	-	-	-
S80825-5mg	99.6%	￥340.00 S80825-5mg ￥340.00 現(xiàn)貨	5 5	-	-	-
S80825-10mg	99.6%	￥595.00 S80825-10mg ￥595.00 現(xiàn)貨	7 7	-	-	-
S80825-25mg	99.6%	￥1275.00 S80825-25mg ￥1275.00 現(xiàn)貨	5 5	-	-	-
S80825-50mg	≥98%	￥2380.00 S80825-50mg ￥2380.00 2-3天	0 貨期：2-3天	-	-	-
S80825-100mg	≥98%	￥3910.00 S80825-100mg ￥3910.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

產(chǎn)品描述：

TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

靶點：

GSK-3β:30 nM (IC50);GSK-3;Autophagy

體內(nèi)研究：

TWS119 (30 mg/kg, i.p.) improves the neurologic function and decreases neurologic deficit dcore in rtPA-treated MCAO rats. TWS119 effectively relieves cerebral edema, and reduces cerebral infarction in rats treated with rtPA. TWS119 also effectively decreases blood-brain barrier permeability in rtPA-Treated MCAO Rats and attenuates rtPA-induced hemorrhage in ischemic brain tissue. Futhermore, TWS119 activates the Wnt/β-Catenin signaling pathway and increases the expression of Claudin-3 and ZO-1

參考文獻：

1. Ding S, et al. Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7. Epub 2003 Jun 6. 2. Wang W, et al. GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53(10):7028-7036. Epub 2015 Dec 15. 3. Chen YQ, et al. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. Exp Cell Res. 2017 Nov 16. pii: S0014-4827(17)30587-6.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.141 ml	15.707 ml	31.414 ml
5 mM	0.628 ml	3.141 ml	6.283 ml
10 mM	0.314 ml	1.571 ml	3.141 ml
50 mM	0.063 ml	0.314 ml	0.628 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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