貨號	規格	價格	上海	北京	武漢	南京
S80816-5mg	≥99%	￥258.40 S80816-5mg ￥258.40 2-3天	0 貨期：2-3天	-	-	-
S80816-10mg	99.8%	￥408.00 S80816-10mg ￥408.00 現貨	3 3	-	-	-
S80816-25mg	99.8%	￥670.00 S80816-25mg ￥670.00 現貨	5 5	-	-	-
S80816-100mg	99.8%	￥1610.00 S80816-100mg ￥1610.00 現貨	2 2	-	-	-

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產品介紹

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

產品描述：

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

靶點：

ATM:12.9 nM (IC50);DNA-PK:2500 nM (IC50);mTOR:9300 nM (IC50);PI3K:16600 nM (IC50)

參考文獻：

1. Hickson I, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 Dec 15;64(24):9152-9 2. Khalil HS, et al. Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.Exp Biol Med (Maywood). 2012 Jun;237(6):622-34. Epub 2012 Jun 22. 3. Kim YD, et al. Orphan nuclear receptor SHP negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of STAT5 transactivation.J Biol Chem. 2012 Sep 12.

溶解性：

DMSO : 80 mg/mL (202.28 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.529 ml	12.643 ml	25.285 ml
5 mM	0.506 ml	2.529 ml	5.057 ml
10 mM	0.253 ml	1.264 ml	2.529 ml
50 mM	0.051 ml	0.253 ml	0.506 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. 梁燕賈珍陳仲海阿良德.七氟烷對大鼠肺缺血再灌注損傷中ATM的影響[J].中國老年學雜志 2018 38(15):3756-3759.

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KU-55933 (ATM Kinase Inhibitor)