貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80800-5mg	99.4%	￥476.00 S80800-5mg ￥476.00 現(xiàn)貨	8 8	-	-	-
S80800-10mg	99.4%	￥570.00 S80800-10mg ￥570.00 現(xiàn)貨	13 >10	-	-	-
S80800-50mg	99.4%	￥1420.00 S80800-50mg ￥1420.00 現(xiàn)貨	16 >10	-	-	-

產(chǎn)品介紹

Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.

產(chǎn)品描述：

Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.

靶點(diǎn)：

TPA-activated PKC:0.85 μM (IC50);PDBu-activated PKC:1.25 μM (IC50);Antibiotic;PKC

體內(nèi)研究：

Valrubicin (3, 6, or 9 mg) reduces tumor growth at week 3 by intratumoral jection in hamster. Valrubicin (6 mg) combined with minimally cytotoxic irradiation (150, 250, or 350 cGy) causes significant tumor shrinkage in hamster. Valrubicin (0.1 μg/μL) significantly reduces the number of infiltrating neutrophils in biopsies challenged with TPA at 24 h and attenuates chronic inflammation in mice. Valrubicin also decreases the expression levels of inflammatory cytokines in the acute model

參考文獻(xiàn)：

1. Chuang LF, et al. Activation of human leukemia protein kinase C by tumor promoters and its inhibition by N-trifluoroacetyladriamycin-14-valerate (AD 32). Biochem Pharmacol. 1992 Feb 18;43(4):865-72. 2. Wani MK, et al. Rationale for intralesional valrubicin in chemoradiation of squamous cell carcinoma of the head and neck. Laryngoscope. 2000 Dec;110(12):2026-32. 3. Hauge E, et al. Topical valrubicin application reduces skin inflammation in murine models. Br J Dermatol. 2012 Aug;167(2):288-95.

溶解性：

DMSO : 125 mg/mL (172.74 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.382 ml	6.91 ml	13.819 ml
5 mM	0.276 ml	1.382 ml	2.764 ml
10 mM	0.138 ml	0.691 ml	1.382 ml
50 mM	0.028 ml	0.138 ml	0.276 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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