貨號	規格	價格	上海	北京	武漢	南京
S80773-2mg	99.1%	￥240.00 S80773-2mg ￥240.00 現貨	4 4	-	-	-
S80773-5mg	99.1%	￥400.00 S80773-5mg ￥400.00 現貨	6 6	-	-	-
S80773-10mg	99.1%	￥640.00 S80773-10mg ￥640.00 現貨	6 6	-	-	-
S80773-25mg	99.1%	￥960.00 S80773-25mg ￥960.00 現貨	6 6	-	-	-
S80773-50mg	≥99%	￥1680.00 S80773-50mg ￥1680.00 2-3天	0 貨期：2-3天	-	-	-
S80773-100mg	≥99%	￥3200.00 S80773-100mg ￥3200.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.

產品描述：

CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.

靶點：

PKD1:182 nM (IC50);PKD3:227 nM (IC50);PKD2:280 nM (IC50);Serine/threoninkinase

體內研究：

Acute administration of the PKD inhibitor CID755673 to normal mice reduces both PKD1 and 2 phosphorylation in a time and dose-dependent manner. Chronic CID755673 administration to T2D db/db mice for two weeks reduces expression of the gene expression signature of PKD activation, enhances indices of both diastolic and systolic left ventricular function and is associated with reduced heart weight

參考文獻：

1. Sharlow ER, et al. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. J Biol Chem. 2008 Nov 28;283(48):33516-26. 2. Venardos K, et al. The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice. PLoS One. 2015 Mar 23;10(3):e0120934.

溶解性：

DMSO : 100 mg/mL (460.36 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.604 ml	23.018 ml	46.036 ml
5 mM	0.921 ml	4.604 ml	9.207 ml
10 mM	0.46 ml	2.302 ml	4.604 ml
50 mM	0.092 ml	0.46 ml	0.921 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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CID755673

3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one