貨號	規格	價格	上海	北京	武漢	南京
S80770-1mg	98.5%	￥42.00 S80770-1mg ￥42.00 現貨	2 2	-	-	-
S80770-5mg	98.5%	￥135.00 S80770-5mg ￥135.00 現貨	2 2	-	-	-
S80770-10mg	98.5%	￥225.00 S80770-10mg ￥225.00 現貨	5 5	-	-	-
S80770-25mg	98.5%	￥460.00 S80770-25mg ￥460.00 現貨	7 7	-	-	-
S80770-50mg	98.5%	￥800.00 S80770-50mg ￥800.00 現貨	3 3	-	-	-
S80770-100mg	≥98%	￥1130.00 S80770-100mg ￥1130.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.

產品描述：

靶點：

Ki: 80 ng/mL (CaM-KKα), 15 ng/mL (CaM-KKβ);CaMK;AMPK;Autophagy

參考文獻：

1. Tokumitsu H, et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. 2. Kukimoto-Niino M, et al. Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9.

溶解性：

DMSO : 6.25 mg/mL (19.89 mM; ultrasonic and warming and heat to 80°C) DMF : 5.56 mg/mL (17.69 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.182 ml	15.909 ml	31.818 ml
5 mM	0.636 ml	3.182 ml	6.364 ml
10 mM	0.318 ml	1.591 ml	3.182 ml
50 mM	0.064 ml	0.318 ml	0.636 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(2篇)

2. [IF=8.786] Meijuan Meng et al."A high-concentrate diet induces inflammatory injury via regulating Ca2+/CaMKKβ-mediated autophagy in mammary gland tissue of dairy cows."Frontiers in Immunology.2023; 14: 1186170 1. [IF=5.714] Meijuan Meng et al."β-carotene alleviates LPS-induced inflammation through regulating STIM1/ORAI1 expression in bovine mammary epithelial cells."INTERNATIONAL IMMUNOPHARMACOLOGY.2022 Dec;113:109377

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STO-609

7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid