貨號	規(guī)格	價格	上海	北京	武漢	南京
S80751-5mg	99.5%	￥560.00 S80751-5mg ￥560.00 現(xiàn)貨	4 4	-	-	-
S80751-10mg	99.5%	￥1040.00 S80751-10mg ￥1040.00 現(xiàn)貨	6 6	-	-	-
S80751-50mg	99.5%	￥4640.00 S80751-50mg ￥4640.00 現(xiàn)貨	3 3	-	-	-

產(chǎn)品介紹

SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.

產(chǎn)品描述：

SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.

靶點：

pIC50: 7.1;TRP/TRPVChannel

體內(nèi)研究：

SB705498 exhibits potent and reversible blockade against the multiple modes of TRPV1 activation, namely the vanilloid (capsaicin), heat- and acid-mediated activation of the receptor. SB705498 displays excellent activity at 10 and 30 mg/kg po with good reversal of allodynia. SB705498 (10 mg/kg p.o.) gives 80% reversal of allodynia in the guinea pig FCA model

參考文獻：

1. Martin J. Gunthorpe, et al. Characterization of SB-705498, a Potent and Selective Vanilloid Receptor-1 (VR1/TRPV1) Antagonist That Inhibits the Capsaicin-, Acid-, and Heat-Mediated Activation of the Receptor. JPET June 2007 vol. 321 no. 3 1183-1192. 2. Rami HK, et al. Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3287-91.

溶解性：

DMSO : 100 mg/mL (232.98 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.33 ml	11.649 ml	23.298 ml
5 mM	0.466 ml	2.33 ml	4.66 ml
10 mM	0.233 ml	1.165 ml	2.33 ml
50 mM	0.047 ml	0.233 ml	0.466 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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