| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S80748-5mg |
99.0% | ￥90.00 | 3 | - | - | - |
|
S80748-10mg |
99.0% | ￥136.00 | 6 | - | - | - |
|
S80748-1mg |
99.0% | ￥197.00 | 9 | - | - | - |
|
S80748-25mg |
99.0% | ￥226.00 | 8 | - | - | - |
|
S80748-50mg |
99.0% | ￥425.00 | 5 | - | - | - |
|
S80748-100mg |
99.0% | ￥750.00 | 2 | - | - | - |
|
GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
| 產品描述： | GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | Gli1/2;Hedgehog/Smoothened;Autophagy | ||||||||||||||||||||
| 體內研究： | GANT-61 (40 mg/kg, i.p., three days per week) inhibits CSC tumor growth in NOD/SCID IL2Rγ null mice. GANT61 (50 mg/kg, p.o.) enhances the effects of chemotherapeutic drugs used in the treatment of neuroblastoma in an additive or synergistic manner and reduces the growth of established neuroblastoma xenografts in nude mice | ||||||||||||||||||||
| 參考文獻： | 1. Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71(3):1092-102. 2. Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330(1):22-32. 3. Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132(7):1516-24. | ||||||||||||||||||||
| 溶解性： | Ethanol : 66.67 mg/mL (155.19 mM; Need ultrasonic) DMSO : 25 mg/mL (58.19 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
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危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京