品牌：源葉(MedMol)

產品編號：S80700 一鍵復制產品信息

CAS號：404951-53-7

分子式：C₂₂H₂₅N₃O₃

分子量：379.4522

別名：達諾司他;達西司特;達諾斯他 DACINOSTAT, NVP-LAQ 824;LAQ824 (DACINOSTAT);2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-;(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(

貨號	規格	價格	上海	北京	武漢	南京
S80700-5mg	97.0%	￥500.00 S80700-5mg ￥500.00 現貨	6 6	-	-	-
S80700-10mg	97.0%	￥900.00 S80700-10mg ￥900.00 現貨	6 6	-	-	-
S80700-50mg	97.0%	￥2700.00 S80700-50mg ￥2700.00 現貨	3 3	-	-	-

產品介紹

Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.

產品描述：

Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.

靶點：

HDAC1:9 nM (IC50);HDAC:32 nM (IC50);HDAC;Autophagy

體內研究：

NVP-LAQ824 produces a dose-dependent inhibition of tumor growth, and at 100 mg/kg, its antitumor effect is similar to that of 5-Fluorouracil

參考文獻：

1. Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64(2):689-95. 2. Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). J Med Chem. 2010 Apr 8;53(7):2952-63. 3. Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11(17):3219-26.

溶解性：

DMSO : ≥ 43 mg/mL (113.32 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.635 ml	13.177 ml	26.354 ml
5 mM	0.527 ml	2.635 ml	5.271 ml
10 mM	0.264 ml	1.318 ml	2.635 ml
50 mM	0.053 ml	0.264 ml	0.527 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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