貨號	規格	價格	上海	北京	武漢	南京	購買數量
S80699-10mg	≥98%	￥350.00 S80699-10mg ￥350.00 2-3天	0 貨期：2-3天	-	-	-
S80699-50mg	≥98%	￥530.00 S80699-50mg ￥530.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.

產品描述：

Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.

靶點：

Wnt, β-catenin;Wnt/beta-catenin

體內研究：

Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression

參考文獻：

1. Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cellsfrom dogs. Am J Vet Res. 2005 May;66(5):885-91. 2. Xu Y, et al. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Mar 22. 3. Lv Y, et al. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370.

溶解性：

Soluble in DMSO、H2O

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.254 ml	21.27 ml	42.541 ml
5 mM	0.851 ml	4.254 ml	8.508 ml
10 mM	0.425 ml	2.127 ml	4.254 ml
50 mM	0.085 ml	0.425 ml	0.851 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

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Pamidronic Acid See P172500