貨號	規格	價格	上海	北京	武漢	南京
S80688-1mg	99.5%	￥216.00 S80688-1mg ￥216.00 現貨	1 1	-	-	-
S80688-2mg	99.5%	￥352.00 S80688-2mg ￥352.00 現貨	4 4	-	-	-
S80688-5mg	99.5%	￥720.00 S80688-5mg ￥720.00 現貨	4 4	-	-	-
S80688-10mg	99.5%	￥960.00 S80688-10mg ￥960.00 現貨	6 6	-	-	-
S80688-25mg	≥98%	￥1920.00 S80688-25mg ￥1920.00 2-3天	0 貨期：2-3天	-	-	-
S80688-50mg	≥98%	￥3600.00 S80688-50mg ￥3600.00 2-3天	0 貨期：2-3天	-	-	-
S80688-100mg	≥98%	￥5600.00 S80688-100mg ￥5600.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication.

產品描述：

YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication.

靶點：

PIKfyve:33 nM (IC50);p110α:3.3 μM (IC50);Autophagy ;InfluenzaVirus;PI3K;Autophagy

參考文獻：

1. Jefferies HB, et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep, 2008, 9(2), 164-170. 2. Ikonomov OC, et al. YM-201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70. 3. Sbrissa D, et al. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM-201636. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46. 4. Dukes JD, et al. The PIKfyve inhibitor YM-201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS One. 2012;7(3):e28659. 5. Ikonomov OC, et al. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.

溶解性：

DMSO : ≥ 47 mg/mL (100.54 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.139 ml	10.696 ml	21.391 ml
5 mM	0.428 ml	2.139 ml	4.278 ml
10 mM	0.214 ml	1.07 ml	2.139 ml
50 mM	0.043 ml	0.214 ml	0.428 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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