貨號	規格	價格	上海	北京	武漢	南京
S80673-5mg	99.9%	￥80.00 S80673-5mg ￥80.00 現貨	10 10	-	-	-
S80673-10mg	99.9%	￥100.00 S80673-10mg ￥100.00 現貨	9 9	-	-	-
S80673-50mg	99.9%	￥350.00 S80673-50mg ￥350.00 現貨	6 6	-	-	-
S80673-100mg	99.9%	￥690.00 S80673-100mg ￥690.00 現貨	5 5	-	-	-

產品介紹

SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

產品描述：

SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

靶點：

IKK-2:11.2 μM (IC50);CDK2/A:61 μM (IC50);AUR2:71 μM (IC50);PRAK:75 μM (IC50);MSK:123 μM (IC50);IκB/IKK;p38MAPK;SerineProtease;CDK;AuroraKinase

體內研究：

SC-514 is efficacious in an acute model of inflammation, namely LPS-induced serum TNFα production in the rat. SC-514 shows a dose-dependent inhibition of TNFα production, validating IKK-2 as a potential anti-inflammatory drug target in vivo. To obtain in vivo evidence for the implication of SC-514 in the response of cancer cells to Fotemustine, the xenograft mouse model of melanoma is used. Nude mice engrafted with A375 or G361 tumors are treated with vehicle control and 25 mg/kg SC-514 and/or 25 mg/kg Fotemustine daily for 13-15 consecutive days and the tumor behavior is monitored. Fotemustine treatment with SC-514 shows a clear combined effect and reduces the size of tumors in mice

參考文獻：

1. Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278(35):32861-71. 2. Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.

溶解性：

DMSO : 50 mg/mL (222.92 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.458 ml	22.292 ml	44.583 ml
5 mM	0.892 ml	4.458 ml	8.917 ml
10 mM	0.446 ml	2.229 ml	4.458 ml
50 mM	0.089 ml	0.446 ml	0.892 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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