貨號	規格	價格	上海	北京	武漢	南京
S80667-2mg	98.7%	￥150.00 S80667-2mg ￥150.00 現貨	9 9	-	-	-
S80667-5mg	98.7%	￥180.00 S80667-5mg ￥180.00 現貨	8 8	-	-	-
S80667-10mg	98.7%	￥290.00 S80667-10mg ￥290.00 現貨	7 7	-	-	-
S80667-25mg	98.7%	￥590.00 S80667-25mg ￥590.00 現貨	6 6	-	-	-
S80667-50mg	98.7%	￥910.00 S80667-50mg ￥910.00 現貨	4 4	-	-	-
S80667-100mg	≥98%	￥1400.00 S80667-100mg ￥1400.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2

產品描述：

靶點：

HSV-1:0.02 μM (IC50);HSV-2:0.02 μM (IC50);DNA/RNASynthesis;HSV

體內研究：

Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase-primase enzyme complex. Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis. Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS.

參考文獻：

1. Ligat G, et al. Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-PrimaseComplex. Front Microbiol. 2018 Oct 23;9:2483. 2. Wald A, et al. Helicase-primase inhibitor Pritelivir for HSV-2 infection. N Engl J Med. 2014 Jan 16;370(3):201-10. 3. Quenelle DC, et al. Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. Antiviral Res. 2018 Jan;149:1-6.

溶解性：

DMSO : ≥ 33 mg/mL (81.99 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.485 ml	12.423 ml	24.845 ml
5 mM	0.497 ml	2.485 ml	4.969 ml
10 mM	0.248 ml	1.242 ml	2.485 ml
50 mM	0.05 ml	0.248 ml	0.497 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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