貨號	規格	價格	上海	北京	武漢	南京
S80641-1mg	99.7%	￥140.00 S80641-1mg ￥140.00 現貨	10 10	-	-	-
S80641-2mg	99.7%	￥240.00 S80641-2mg ￥240.00 現貨	10 10	-	-	-
S80641-5mg	99.7%	￥330.00 S80641-5mg ￥330.00 現貨	7 7	-	-	-
S80641-10mg	99.7%	￥590.00 S80641-10mg ￥590.00 現貨	7 7	-	-	-
S80641-25mg	99.7%	￥1370.00 S80641-25mg ￥1370.00 現貨	4 4	-	-	-
S80641-50mg	≥99%	￥2380.00 S80641-50mg ￥2380.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

GlyH-101 is a potent CFTR inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current

產品描述：

靶點：

CFTR;CFTR;Autophagy

體內研究：

GlyH-101 (2.5 μg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse

參考文獻：

1. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124(2):125-37. 2. Kelly M, et al. Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition. J Pharmacol Exp Ther. 2010 Apr;333(1):60-9. 3. Barman PP, et al. Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101. Biochem Biophys Res Commun. 2011 Apr 29;408(1):12-7. 4. Melis N, et al. Revisiting CFTR inhibition: a comparative study of CFTRinh -172 and GlyH-101 inhibitors. Br J Pharmacol. 2014 Aug;171(15):3716-27. 5. Muanprasat C, et al. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug;124(2):125-37.

溶解性：

DMSO : ≥ 58 mg/mL (117.61 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.028 ml	10.139 ml	20.278 ml
5 mM	0.406 ml	2.028 ml	4.056 ml
10 mM	0.203 ml	1.014 ml	2.028 ml
50 mM	0.041 ml	0.203 ml	0.406 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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GlyH-101

N-2-Naphthalenyl-glycine 2-[(3,5-Dibromo-2,4-dihydroxyphenyl)methylene]hydrazide