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產品描述： IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth |
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靶點：
IC50: 26 nM (Notch);Gamma-secretase |
體內研究：
IMR-1 (i.p.; 15mg/kg; for 28 days) inhibits Notch-dependent tumor growth in patient-derived xenograft models. Animal Model: Nude mouses with adenocarcinoma xenograft Dosage: 15mg/kg Administration: I.p.; for 28 days Result: Blocks tumor establishment. |
參考文獻：
1. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603. |
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溶解性：
soluble in DMSO |
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保存條件：
-20℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
2.83 ml |
14.148 ml |
28.295 ml |
| 5 mM |
0.566 ml |
2.83 ml |
5.659 ml |
| 10 mM |
0.283 ml |
1.415 ml |
2.83 ml |
| 50 mM |
0.057 ml |
0.283 ml |
0.566 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
北京