貨號	規格	價格	上海	北京	武漢	南京
S80549-1mg	98.4%	￥90.00 S80549-1mg ￥90.00 現貨	10 10	-	-	-
S80549-2mg	98.4%	￥120.00 S80549-2mg ￥120.00 現貨	10 10	-	-	-
S80549-5mg	98.4%	￥180.00 S80549-5mg ￥180.00 現貨	9 9	-	-	-
S80549-10mg	98.4%	￥340.00 S80549-10mg ￥340.00 現貨	12 >10	-	-	-
S80549-25mg	98.4%	￥550.00 S80549-25mg ￥550.00 現貨	9 9	-	-	-
S80549-100mg	98.4%	￥840.00 S80549-100mg ￥840.00 現貨	6 6	-	-	-

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產品介紹

GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms

產品描述：

GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms

靶點：

c-Raf:9 nM (IC50);Apoptosis;Raf

體內研究：

GW5074 (5 mg/Kg) completely prevents extensive bilateral striatal lesions induced by 3-NP in mice. GW5074 suppresses sidestream smoke-induced airway hyperresponsiveness in mice

參考文獻：

1. Chin PC, et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem, 2004, 90(3), 595-608. 2. Lei Y, et al. The Raf-1 inhibitor GW5074 and NSC 34521 suppress sidestream smoke-induced airway hyperresponsiveness in mice. Respir Res, 2008, 9(1), 71.

溶解性：

DMSO : 100 mg/mL (191.96 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.92 ml	9.598 ml	19.196 ml
5 mM	0.384 ml	1.92 ml	3.839 ml
10 mM	0.192 ml	0.96 ml	1.92 ml
50 mM	0.038 ml	0.192 ml	0.384 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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