貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80543-5mg	98.5%	￥110.00 S80543-5mg ￥110.00 現(xiàn)貨	3 4 3	4	-	-
S80543-10mg	98.5%	￥210.00 S80543-10mg ￥210.00 現(xiàn)貨	4 4	-	-	-
S80543-50mg	98.5%	￥700.00 S80543-50mg ￥700.00 現(xiàn)貨	1 1	-	-	-
S80543-100mg	98.5%	￥1210.00 S80543-100mg ￥1210.00 現(xiàn)貨	7 7	-	-	-
S80543-1g	98.5%	￥4500.00 S80543-1g ￥4500.00 現(xiàn)貨	8 8	-	-	-

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產(chǎn)品介紹

Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 μM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects

產(chǎn)品描述：

靶點(diǎn)：

Macrolide;Antibacterial;Antibiotic

體內(nèi)研究：

In the lungs of both A pleuropneumoniae- and zymosan-challenged pigs, Tulathromycin A (2.5 mg/kg, IM) promotes leukocyte apoptosis and efferocytosis and inhibites proinflammatory leukotriene B4 production, with a concurrent reduction in leukocyte necrosis relative to that of control pigs. Tulathromycin A also attenuates the degree of lung damage and lesion progression in A pleuropneumoniae-inoculated pigs

參考文獻(xiàn)：

1. Villarino N, et al. Pharmacokinetics of tulathromycin in healthy and neutropenic mice challenged intranasally with lipopolysaccharide from Escherichia coli. Antimicrob Agents Chemother. 2012;56(8):4078-4086. 2. Andersen NM, et al. Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob Agents Chemother. 2012;56(11):6033-6036. 3. Duquette SC, et al. Immunomodulatory effects of tulathromycin on apoptosis, efferocytosis, and proinflammatory leukotriene B4 production in leukocytes from Actinobacillus pleuropneumoniae-or zymosan-challenged pigs. Am J Vet Res. 2015;76(6):507-519.

溶解性：

DMSO : 50 mg/mL (62.03 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.241 ml	6.203 ml	12.406 ml
5 mM	0.248 ml	1.241 ml	2.481 ml
10 mM	0.124 ml	0.62 ml	1.241 ml
50 mM	0.025 ml	0.124 ml	0.248 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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