貨號	規格	價格	上海	北京	武漢	南京
S80541-5mg	99.4%	￥315.00 S80541-5mg ￥315.00 現貨	9 9	-	-	-
S80541-10mg	99.4%	￥550.80 S80541-10mg ￥550.80 現貨	4 4	-	-	-
S80541-50mg	99.4%	￥1972.00 S80541-50mg ￥1972.00 現貨	2 2	-	-	-

產品介紹

SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.

產品描述：

SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.

靶點：

FGFR;PDGFR;VEGFR;VEGFR;FGFR;PDGFR

體內研究：

In mice, SU5416 (25 mg/kg, i.p.) inhibits subcutaneous growth of a panel of tumor cell lines by inhibiting the angiogenic process associated with tumor growth.

細胞實驗：

Tumor cell lines used in the in vitro growth are cultured in media at 37°C in 5–10% CO2. SU5416 is serially diluted in media containing DMSO (<0.5%) and added to cultures of tumor cells 1 day after the initiation of culture. Cell growth is measured after 96 h using the sulforhodamine B method. IC50s are calculated by curve fitting using four-parameter analysis.(Only for Reference)

參考文獻：

1.Li Y, et al. Calcif Tissue Int. 2013, 93(6), 556-5 64. 2.Sun L, et al. J Med Chem. 1999, 42(25), 5120-5130. 3.Lo AK, et al. J Pathol. 2015. doi: 10.12002/path.4575. 4.Fong TA, et al. Cancer Res. 1999, 59(1), 99-106. 5.Trzcińska-Daneluti AM, et al. RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. Mol Cell Proteomics. 2015 Jun;14(6):1569-83.

溶解性：

DMSO:29.6 mg/mL (100 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.375 ml	16.874 ml	33.747 ml
5 mM	0.675 ml	3.375 ml	6.749 ml
10 mM	0.337 ml	1.687 ml	3.375 ml
50 mM	0.067 ml	0.337 ml	0.675 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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SU 5402