貨號	規格	價格	上海	北京	武漢	南京
S80539-5mg	99.4%	￥160.00 S80539-5mg ￥160.00 現貨	6 6	-	-	-
S80539-25mg	99.4%	￥296.00 S80539-25mg ￥296.00 現貨	10 10	-	-	-
S80539-100mg	99.4%	￥800.00 S80539-100mg ￥800.00 現貨	3 3	-	-	-

產品介紹

CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1.

產品描述：

CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1.

靶點：

MEK1:17 nM (IC50);Apoptosis;MEK

體內研究：

The systemic administration of the MEK inhibitor CI-1040 reduces adenoma formation to a third and significantly restores lung structure. The proliferation rate of lung cells of mice treated with CL-1040 is decreased without any obvious effects on differentiation of pneumocytes

參考文獻：

1. Allen LF, et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol. 2003 Oct;30(5 Suppl 16):105-16. 2. Wei CR, et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20(10):1961-8. 3. Kramer BW, et al. Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040strongly reduces growth and improves lung structure. BMC Cancer. 2004 Jun 1;4:24.

溶解性：

DMSO : ≥ 100 mg/mL (208.92 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.089 ml	10.446 ml	20.892 ml
5 mM	0.418 ml	2.089 ml	4.178 ml
10 mM	0.209 ml	1.045 ml	2.089 ml
50 mM	0.042 ml	0.209 ml	0.418 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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PD184352 (CI-1040)