貨號	規格	價格	上海	北京	武漢	南京
S80538-5mg	99.5%	￥300.00 S80538-5mg ￥300.00 現貨	3 3	-	-	-
S80538-10mg	99.5%	￥450.00 S80538-10mg ￥450.00 現貨	7 7	-	-	-
S80538-25mg	99.5%	￥870.00 S80538-25mg ￥870.00 現貨	6 6	-	-	-
S80538-50mg	99.5%	￥1400.00 S80538-50mg ￥1400.00 現貨	3 3	-	-	-

產品介紹

Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM.

產品描述：

Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM.

靶點：

VEGFR2:37 nM (IC50);VEGFR

體內研究：

Vatalanib induces dose-dependent inhibition of the angiogenic response to VEGF and PDGF in both a growth factor implant model and a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg). In the same dose range, Vatalanib also inhibits the growth and metastasesof several human carcinomas in nude mice without significant effect on circulating blood cells or bone marrow leukocytes

參考文獻：

1. Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000, 60(8 2. Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011, 18(2), 589-596. 3. Wan J, et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016 Mar;35(3):1297-308.

溶解性：

DMSO : 125 mg/mL (360.43 mM; Need ultrasonic and warming)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.883 ml	14.417 ml	28.834 ml
5 mM	0.577 ml	2.883 ml	5.767 ml
10 mM	0.288 ml	1.442 ml	2.883 ml
50 mM	0.058 ml	0.288 ml	0.577 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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