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Z-IETD-FMK

    
98%

Z-IETD-FMK

源葉(MedMol)
S80534 一鍵復制產品信息
210344-98-2
C30H43FN4O11
654.6810232
貨號 規格 價格 上海 北京 武漢 南京 購買數量
S80534-1mg 98% ¥672.00 2 - - -
S80534-5mg 98% ¥1520.00 貨期:2-3天 - - -
S80534-25mg 98% ¥3840.00 1 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK)是一種特異性Caspase-8抑制劑。Z-IETD-FMK也是顆粒酶B(granzyme B)抑制劑

產品描述: Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK)是一種特異性Caspase-8抑制劑。Z-IETD-FMK也是顆粒酶B(granzyme B)抑制劑
靶點: Caspase-8;Caspase
體外研究: Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures.
體內研究: In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries.
細胞實驗: Cell lines: Rat neonatal cardiomyocytes Concentrations: 50 μM Incubation Time: 24 h Method: Drugs were added to the cell culture medium simultaneously with ceramide, and surviving cells were counted 24 hours later.
動物實驗: Animal Models: T. cruzi-infected mice Dosages: 0.4 mg/3 days Administration: --
參考文獻: 1. Tezel G, et al. Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci. 1999, 40(11), 2660-2667. 2. Wang J, et al. Involvement of caspase 3- and 8-like proteases in ceramide-induced apoptosis of cardiomyocytes. J Card Fail. 2000, 6(3), 243-249. 3. Silva EM, et al. Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection. J Immunol. 2005, 174(10), 6314-6321. 4. Monnier PP, et al. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J Neurosci. 2011, 31(29), 10494-10505.
溶解性: soluble  in  DMSO
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 1.527 ml 7.637 ml 15.275 ml
5 mM 0.305 ml 1.527 ml 3.055 ml
10 mM 0.153 ml 0.764 ml 1.527 ml
50 mM 0.031 ml 0.153 ml 0.305 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

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批號:JS298415 貨號:S20001-25g
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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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